https://www.universite-paris-saclay.fr/en/csc-joint-doctoral-program-universite-paris-saclay-and-china-scholarship-council Discipline:ChemistryKeywords:Organic Chemistry, Total Synthesis Doctoral School:Chemical sciences: Molecules, Materials, Instrumentation and Biosystems (2MIB)-n°571Host Institute: Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO), UMR 8182, Université Paris Saclay, Orsay, Francehttps://www.icmmo.universite-paris-saclay.fr/fr/Host Group:Méthodologie, Synthèse et Molécules Thérapeutiques https://www.icmmo.universite-paris-saclay.fr/fr/equipes/msmt/ PhD Supervisor:Dr. Guillaume Vincent (Directeur de Recherche)guillaume.vincent@universite-paris-saclay.frhttps://www.icmmo.universite-paris-saclay.fr/fr/perso/guillaume-vincent/Project descriptionTotal Synthesis of Terpeneshttps://www.adum.fr/as/ed/voirproposition.pl?site=PSaclay&matricule_prop=44720&langue=enOur team has been involved for several years in the development of synthetic methodology in order to accomplish the total synthesis of highly complex indole alkaloids. For instance, we developed several oxidative coupling methods between indole and phenols1that culminated in the semisynthesis of voacalgine A and bipleiophylline.2We also achieved the total synthesis of 17-nor-excelsinidine,316-epi-pleiocarpamine, 16-hydroxymethyl-pleiocarpamine, taberdivarineH4as well as cymoside5or ophiorrhineA.6
The aim of this project is achieve the total synthetic of complex natural products in association with the development of related synthetic methods in the fields of oxidative couplings, cationic rearrangement and polycyclization. These methods would be inspired by the biosynthesis of the natural products. We are currently interested in the total synthesis of terpenes and we are therefore targeting the total synthesis of krishnolides, khayalactone or croyanoid A who are natural products which are isolated from various plant
s.7
Profile and skills required:Master student in organic chemistryLevel of required English: IntermediateReferences:
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